Btk Phospho (pY223) (BTK)_珈得尔化学试剂

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Btk Phospho (pY223) (BTK)

Rabbit Monoclonal Antibody

别名：	BTK,AGMX1, AT, ATK, BPK, IMD1, MGC126261, MGC126262, PSCTK1, XLA,Tyrosine-protein kinase BTK,Bruton tyrosine kinase
Cas号：	--	M D L：	--
分子式：	--	分子量：	--

货号	品名	规格	包装	单价	货期	库存
JD1227177581	Btk Phospho (pY223) (BTK)	--	100ul	0元	现货	3天

物流提示：偏远地区如新疆西藏宁夏甘肃等地可能无法运送液体，下单前请联系客服。

性状：

【反应特异性】Human , Mouse , Rat
【克隆 ID】EP420Y
【用途】WB , IP
【抗原分子量】77 kDa

质量标准：

【产品介绍】Btk (Bruton tyrosine kinase also known as BPK
or ATK) is a member of the TEC family of
non-receptor protein tyrosine kinase which includes Bmx,
Itk and TEC. Btk is composed of a pleckstrin domain, an
SH3 and SH2 domain, a catalytic kinase domain and a
TEC homology domain (1). Tec family protein tyrosine
kinases (TFKs) play a central role in hematopoietic
cellular signaling. Initial activation takes place
through specific tyrosine phosphorylation situated in
the activation loop. Further activation occurs within
the SH3 domain via a transphosphorylation mechanism,
which for Bruton's tyrosine kinase (Btk) affects
tyrosine 223. (2). Similar to Etk-TNFR2 interaction,
Btk interacts with Fas, a member of the TNFR family
involved in apoptosis in a ligand-independent manner
(3). Btk can be activated through
intramolecular autophosphorylation at tyrosine 551 and
that Btk autophosphorylation is required for Btk
catalytic functions (4).

Recommended Applications

WB, IP
Applications and Recommended Dilution Factors

WB: 1:10,000 - 50,000
IP: 1:40
Species Reactivity *

Human, Mouse, Rat

*Mouse and Rat reactivity predicted based on sequence alignment only, not based on testing

Products Data

A. Western blot analysis on Ramos cell lysates
using anti-Phospho-BTK (pY223) RabMAb (cat. #2207-1).
Cells were either (A) untreated (B) treated with
pervanadate.

Specificity

A phospho specific peptide corresponding to
residues surrounding tyrosine 223 of human BTK was used
as an immunogen. This antibody detects BTK phosphorylated
on tyrosine 223.

贮存：

Storage Condition and Buffer

Store at -20 °C. Buffer: 50 mM Tris-Glycine (pH 7.4),
0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05%
BSA. Stable for 12 months from date of receipt.