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| 货号 | 品名 | 规格 | 包装 | 单价 | 货期 | 库存 |
| JD1227177592 | CaMKII (CAMK2B) | -- | 100ul | 0元 | 现货 | 3天 |
| 性状： | 【反应特异性】Human , Mouse , Rat 【克隆 ID】EPR6685(B) 【用途】WB , FC 【抗原分子量】45 - 70kDa |
| 质量标准： | 【产品介绍】Calcium/calmodulin-dependent protein kinase II (CaMKII) is a widely distributed protein kinase that regulates numerous physiological functions. Inhibitors of CaMKII are useful tools for investigating the CaMKII functions (1). The synapse contains densely localized and interacting proteins that enable it to adapt to changing inputs. A Ca2+-sensitive protein complex is involved in the regulation of AMPA receptor synaptic plasticity. The complex is comprised of MUPPI, a multi-PDZ domain-containing protein; SynGAP, a synaptic GTPase-activating protein; and the Ca2+/calmodulin-dependent kinase CaMKII. In synapses of hippocampal neurons, SynGAP and CaMKII are brought together by direct physical interaction with the PDZ domains of MUPP1, and in this complex, SynGAP is phosphorylated. Ca2+CaM binding to CaMKII dissociates it from the MUPP1 complex, and Ca2+ entering via the NMDAR drives the dephosphorylation of SynGAP (2).
WB, FC WB: 1:1,000 - 10,000 Human, Mouse, Rat *Species cross-reactivity is based on WB analysis. Products Data Western blot analysis on (A) human pancreas, (B) Flow cytometric analysis of permeabilized C6 cells
A synthetic peptide corresponding to residues in Storage Condition and Buffer Store at -20° C. Buffer: Antibody buffer, sodium |
