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| 货号 | 品名 | 规格 | 包装 | 单价 | 货期 | 库存 |
| JD1227179007 | IRS-2 (IRS2) | -- | 100ul | 0元 | 现货 | 3天 |
| 性状： | 【产品类型】Rabbit Monoclonal IgG 【反应特异性】Human 【克隆 ID】EP903Y 【用途】WB , ICC , IP 【产品性状】 【阳性对照】 【产品浓度】 【细胞定位】 【抗原分子量】170 185 kDa |
| 质量标准： | 【产品介绍】Insulin recept o r substrates (IRS), the maj o r intracellular substrates of the insulin recept o r (IR), are adapt o r proteins that transduce signals from the IR to downstream effect o r s that are imp o r tant f o r the biological effect of insulin (1-2). After insulin stimulation, IRS proteins are rapidly phosph o r ylated on multiple tyrosine residues. Once phosph o r ylated, IRS proteins bind a n d activate Grb-2, SHP2 a n d the PI3-K p85 subunit (2-3). Sequences of IRS-2 a n d IRS-1 reveal a highly conserved amino terminus containing a pleckstrin-homology domain a n d a phosphotyrosine-binding domain, a n d a po o r ly conserved carboxy terminus containing several tyrosine phosph o r ylation motifs. IRS-2 is expressed in many cells, including tissues from IRS-1-/- mice, a n d may be essential f o r signaling by several recept o r systems such as insulin a n d cytokine (1). Recommended Applications A. Western blot analysis on 293 + insulin cell lysate |
| 贮存： | Store at -20 °C. Buffer: 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. Stable for 12 months from date of receipt. |
