|
![]() |
货号 | 品名 | 规格 | 包装 | 单价 | 货期 | 库存 |
JD1227179010 | JAK2 Phospho (pY1007/1008) | -- | 100ul | 0元 | 现货 | 3天 |
性状: | 【产品类型】Rabbit Monoclonal IgG 【反应特异性】Human , Mouse , Rat 【克隆 ID】E132 【用途】WB , IHC , ICC , IP 【产品性状】 【阳性对照】 【产品浓度】 【细胞定位】 【抗原分子量】130 kDa |
质量标准: | 【产品介绍】Jak2 is a member of the Janus family tyrosine kinases (Jaks), whose function is to transduce extracellular signals from cytokines a n d interferons. Jaks associate with cytokine recept o r s; upon lig a n d binding, Jaks phosph o r ylate the recept o r . The phosph o r ylated recept o r s are bound by SH2-containing proteins, one class of which is the signal transducers a n d activat o r s of transcription (STATs). Activated STATs, then, translocate to the nucleus to mediate gene transcription (1,2). Tyr1007/1008 of Jak2 are the homologous Tyr1054/1055 in Tyk2, a n d phosph o r ylation at these residues is needed f o r Tyk2 activation (3). A chromosomal aberration involving Jak2 is found in a f o r m of pre-B acute myeloid leukemia (4). WB: 1:5,000-10,000 A. Western blot analysis of immunoprecipitation pellets B. Immunohistochemical analysis of paraffin-embedded C. Dot Blot analysis on immunogen phospho-peptide (A) |