Recombinant Human Beta Defensin-1是一种抗菌肽，能够保护上皮表面，包括皮肤，胃肠道和呼吸道。
Synonyms
rHuBD-1; HBD1; DEFB1 ; 重组人 β-防御素-1
Species
HumanSource
E. coli Accession
P60022 Gene ID
1672 Molecular Weight
Approximately 5.1 kDa AA Sequence
GNFLTGLGHR SDHYNCVSSG GQCLYSACPI FTKIQGTCYR GKAKCCK Biological Activity
Full biological activity determined by a chemotaxis bioassay using CD34+ dendritic cells is in a concentration range of 100-1000 ng/mL. Appearance
Lyophilized powder. Formulation
Lyophilized after extensive dialysis against 20 mM PBS, pH 7.4, 130 mM NaCl. Endotoxin Level
<1 EU/μg, determined by LAL method. Reconstitution
Reconstitute the lyophilized recombinant Human Beta Defensin-1 (rHuBD-1) to 0.1-1.0 mg/mL using sterile distilled water or aqueous buffer containing 0.1% BSA. Storage & Stability
Lyophilized recombinant Human Beta Defensin-1 (rHuBD-1) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping
Room temperature in continental US; may vary elsewhere. Background
Recombinant Human Beta Defensin-1 is an antimicrobial peptide that defends epithelial surfaces including the skin, gastrointestinal, and respiratory tracts[1]. Human Beta Defensin-1 may provide a fast-acting antimicrobial coating of tubular lumens in the upper urinary tract to prevent infection by inhibiting bacterial attachment to the urothelium and serving as a second-line chemical shield[2]. |
