Recombinant Human Eotaxin-2/CCL24 诱导 CCR3 携带嗜酸性粒细胞、肥大细胞、嗜碱性粒细胞和Th2细胞等，这些细胞均在过敏性细胞中发挥作用。
Synonyms
rHuEotaxin-2/CCL24; C-C motif chemokine 24; CK-beta-6; MPIF-2; MPIF2; SCYA24 ; 重组人嗜酸性细胞趋化因子 (CCL24)
Species
HumanSource
E. coli Accession
O00175 Gene ID
6369 Molecular Weight
Approximately 8.8 kDa AA Sequence
VVIPSPCCMF FVSKRIPENR VVSYQLSSRS TCLKAGVIFT TKKGQQFCGD PKQEWVQRYM KNLDAKQKKA SPRARAVA Biological Activity
Full biological activity determined by a chemotaxis bioassay using human peripheral blood eosinophils is in a concentration of 50-100 ng/ml. Appearance
Lyophilized powder. Formulation
Lyophilized after extensive dialysis against 20 mM PB, pH 7.4, 150 mM NaCl. Endotoxin Level
<1 EU/μg, determined by LAL method. Reconstitution
Reconstitute the lyophilized recombinant Human Eotaxin-2/CCL24 (rHuEotaxin-2/CCL24) to 0.1-1.0 mg/mL using sterile distilled water or aqueous buffer containing 0.1% BSA. Storage & Stability
Lyophilized recombinant Human Eotaxin-2/CCL24 (rHuEotaxin-2/CCL24) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping
Room temperature in continental US; may vary elsewhere. Background
CCL24 mainly mediates atopic disorders, parasitic infections and systemic diseases via binding to its only receptor CCR3. CCL24 increases the proliferation and apoptosis of DSCs, whereas on the whole it promotes the number of DSCs. CCL24 is a beneficial factor for the process of decidualization in human early pregnancy[1]. |
