Recombinant Human Interleukin-8/CXCL8 (CHO-expressed) 是促炎性CXC趋化因子,与促进中性粒细胞趋化性和脱颗粒有关。 Synonyms rHuIL-8/CXCL8; C-X-C motif chemokine 8; NAP-1; IL8; GCP-1 ; 重组人白细胞介素- 8/CXCL8 (CHO 表达) Species Human Source CHO Accession P10145 Gene ID 3576 Molecular Weight Approximately 9 kDa AA Sequence AVLPRSAKEL RCQCIKTYSK PFHPKFIKEL RVIESGPHCA NTEIIVKLSD GRELCLDPKE NWVQRVVEKF LKRAENS Biological Activity The ED50 is <6 ng/mL as measured by CHO/Gα15 cells. Appearance Lyophilized powder. Formulation Lyophilized after extensive dialysis against PBS. Endotoxin Level <0.2 EU/μg, determined by LAL method. Reconstitution Reconstitute the lyophilized recombinant Human Interleukin-8/CXCL8 (CHO-expressed) (rHuIL-8/CXCL8) to 100 µg/mL using ddH2O. Storage & Stability Lyophilized recombinant Human Interleukin-8/CXCL8 (CHO-expressed) (rHuIL-8/CXCL8) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping Room temperature in continental US; may vary elsewhere. Background Interleukin-8 induces the full pattern of responses observed in chemotactically stimulated neutrophils, i.e., activation of the motile apparatus and directional migration, expression of surface adhesion molecules, release of storage enzymes, and production of reactive oxygen metabolites[1]. Human recombinant IL-8 is potently angiogenic when implanted in the rat cornea and induced proliferation and chemotaxis of human umbilical vein endothelial cells[2]. |