Recombinant Human PVR/CD155, His (HEK293-expressed)，是免疫球蛋白超家族中的一种I型跨膜糖蛋白，参与人类动物细胞脊髓灰质炎病毒感染和肠道体液免疫反应。
Synonyms
rHuPVR/CD155, His; CD155; NECL-5; PVR ; 重组人PVR/CD155, His (HEK293表达)
Species
HumanSource
HEK 293 Accession
P15151 Gene ID
5817 Molecular Weight
50-65 kDa AA Sequence
WPPPGTGDVV VQAPTQVPGF LGDSVTLPCY LQVPNMEVTH VSQLTWARHG ESGSMAVFHQ TQGPSYSESK RLEFVAARLG AELRNASLRM FGLRVEDEGN YTCLFVTFPQ GSRSVDIWLR VLAKPQNTAE VQKVQLTGEP VPMARCVSTG GRPPAQITWH SDLGGMPNTS QVPGFLSGTV TVTSLWILVP SSQVDGKNVT CKVEHESFEK PQLLTVNLTV YYPPEVSISG Y Biological Activity
5 µg/mL (100 µL/well) of immoblized recombinant human PVR/CD155-His can bind human TIGIT-Fc with a linear range of 2.5-10 μg/mL. Appearance
Lyophilized powder. Formulation
Lyophilized after extensive dialysis against PBS, 5% trehalose and mannitol. Endotoxin Level
<0.2 EU/μg, determined by LAL method. Reconstitution
Reconstitute the lyophilized recombinant Human PVR/CD155, His (HEK293-expressed) (rHuPVR/CD155, His) to 100 µg/mL using ddH2O or diluted with PBS. Storage & Stability
Lyophilized recombinant Human PVR/CD155, His (HEK293-expressed) (rHuPVR/CD155, His) is stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage. Shipping
Room temperature in continental US; may vary elsewhere. Background
CD155 is a Type I transmembrane glycoprotein in the immunoglobulin superfamily[1]. Commonly known as Poliovirus Receptor (PVR) due to its involvement in the cellular poliovirus infection in primates, CD155's normal cellular function is in the establishment of intercellular adherens junctions between epithelial cells. The role of CD155 in the immune system is unclear, though it may be involved in intestinal humoral immune responses. CD155 may also be used to positively select MHC-independent T cells in the thymus[2]. |
